Identification of migratory cells expressing stem cell markers in 3D models of oral squamous cell carcinoma. DE Costea*, Amani H. Osman, Evelyn Neppelberg, Gunnvor Øjordsbakken, Anne Chr. Johannessen, IAOP, Seoul, Korea, 2010, oral presentation.
Oral carcinoma-associated fibroblasts display different functional and electrophysiological properties from normal oral fibroblasts,X Liang*, FH Labeed, R Abdallat, E Neppelberg, AC Johannessen1, O Tsinkalovsky and DE Costea, American Association for Cancer Research (AACR) 101st Annual Meeting 2010, April 17-21, 2010, Washington DC, USA, poster
Rapid adherence to collagen IV enriches for tumour initiating cells , X Liang*, FH Labeed, R Abdallat, AC Johannessen, O Tsinkalovsky, J Wang and DE Costea, The European Association for Cancer Research (EACR) 21 – 21st Meeting of the European Association for Cancer Research, 26 – 29 June 2010, Oslo, Norway, poster presentation
Characterization of Cells Derived from Human Epithelial Rests of Malassez, K. Kitajima, X. Liang*, E. Fick, E Neppelberg, DE Costea, and M. Igarashi, Dental Research (IADR) General Session, July 14-17, 2010, Barcelona, Spain, poster
Rapid adherence to collagen IV enriches for tumour initiating cells, X Liang*, J Wang, O Tsinkalovsky, AC Johannessen, PO. Enger, and DE Costea, International Association for Dental Research (IADR) General Session, July 14-17, 2010, Barcelona, Spain, poster presentation and oral presentation in Hatton Award Competition.
Enhanced Self-Renewal Properties of Transformed Oral Epithelial Cells after Interactions with Stromal Fibroblasts, DE Costea*, AH Osman, A Ipatova, D Sapkota, E Neppelberg, L Harper, IC Mackenzie, OK Vintermyr, and AC Johannessen, IAOO, Toronto, Canada, 2009, oral presentation.
Normal oral keratinocytes stimulate clonal expansion of oral squamous cell carcinoma-derived cells being in turn growth-inhibited and induced into apoptosis Costea DE*, Nilsson H, Tsinkalovsky O, Gemenetzidis E, Otterlei M, Neppelberg E, Vintermyr OK, Mackenzie IC, Johannessen AC, Keystone Symposium on Tumour Microenvironment, Vancouver, 2009, poster
Carcinoma cells expressing stem cell markers show selective survival associated with apoptotic resistance and cell cycle changes, Daniela Elena Costea*, Lisa Harper, Luke Gammon, Ian C. Mackenzie., AACR, Denver, US, 2009, poster
In Vitro Reconstruction of Human Sulcular Epithelium, G. Dabija*, E. Neppelberg, Ø. Nielsen, M. Cimpan, V. Bakken, A.C. Johannessen, and D.E. Costea, Pan-European Federation for Dental Research, London, UK, 12-15th September 2008, oral presentation.
CD44+ carcinoma cells show apoptotic resistance and cell cycle differences, L. Gammon*, D.E. Costea, L. Harper, and I. Mackenzie, Pan-European Federation for Dental Research, London, UK, 12-15th September 2008, , oral presentation.
FOXM1 is Upregulated in Oral Cancer and Induces Genomic Instability
E. Gemenetzidis*, D.E. Costea, T. Chaplin, B.D. Young, F. Fortune, and M.T. The Pan-European Federation for Dental Research, London, UK, 12-15th September 2008, oral presentation.
CD44 down-regulation reduces self-renewal of oral carcinoma stem cells F.K. Kidwai, D.E. Costea, L. Gammon, L. Harper, and I.C. Mackenzie* Pan-European Federation for Dental Research, London, UK, 12-15th September 2008, , oral presentation.
Stromal fibroblasts enhance self renewal properties of transformed oral keratinocytes, D.E. Costea*, E. Neppelberg, L.J. Harper, F. Chaudry, I.C. Mackenzie, O.K. Vintermyr, and A.C. JohannessenPan-European Federation for Dental Research, London, UK, 12-15th September 2008, poster
Stromal fibroblasts enhance clonogenic growth of transformed oral keratinocytes, DE Costea*, E Neppelberg, L Harper, F Chaudry, IC Mackenzie, OK Vintermyr, and AC Johannessen12th International Congress on Oral Cancer, Shanghai, China, 22-25th of May 2008, , oral presentation
Generation of skin and oral mucosa from mouse embryonic stem cells under the influence of regional specific components, DE Costea*, L Harper, K Kitajima, IC. Mackenzie, International Investigative Dermatology Annual Meeting, 12-17 May, 2008, poster
The colony forming ability of HNSCC lines in-vitro, poster, K. Kitajima*, L.J. Harper, D.E. Costea, and I. Mackenzie, International Association of Dental Research, 86th General Session & Exhibition, Toronto, Canada, 1-5th July 2008, , poster
Khat Induces Abnormal Differentiation of Reconstituted Human Oral Mucosa, O. Lukandu*, D.E. Costea, O.K. Vintermyr, and A.C. Johannessen, American Association of Dental Research, 37th Annual Meeting and Exhibition, Dallas, US, 31st of March-5th of April 2008, poster
Tumour associated fibroblasts increase self renewal properties of transformed oral keratinocytes, DE Costea*, E Neppelberg, L Harper, F Chaudry, OK Vintermyr, IC Mackenzie, AC Johanessen, Stem cell AbCam meeting, 13-17 Dec 2007, Punta Cana, Dominican Republic, oral presentation.
Reactive Oxygen Species Mediate Khat Induced Cytotoxicity in Oral Cells, O. Lukandu*, D.E. Costea, E. Dimba, O. Vintermyr, and A. Johannessen, 42nd annual meeting of IADR-Continental European and Israeli Divisions Sept 26th – 29th, 2007, Thessaloniki, Greece, oral presentation.
The cd44+ fraction of carcinoma cells shows apoptotic resistance and spends an extended time in the g2 phase of the cell cycle, I.C.Mackenzie*, D. Costea, L. Harper, Stem Cell Gordon Conference, Montana, US, 9-12 September 2007, oral presentation.
0ral malignancies show similar hierarchical stem cell patterns in vivo and in vitro, D. Costea*, L. Harper and I.C.Mackenzie, First International Stem Cell Meeting, Tel Aviv, Israel, 2007, 2-5 June, 2007, poster.
Tumour initiating cells spend an extended time in the g2 phase of the cell cycle, I.C.Mackenzie*, D. Costea, L. Harper, First International Stem Cell Meeting, Tel Aviv, Israel, 2007, 2-5 June, 2007, oral presentation.
Differential apoptotic cell responses within malignant cell lines, L. Harper*, D. Costea, and I.C.Mackenzie, First International Stem Cell Meeting, Tel Aviv, Israel, 2007, 2-5 June, 2007, poster.
Oral Squamous Cell Carcinoma Cells Inhibit the Growth of Normal Oral Keratinocytes
– a Putative Mechanism for Intraepithelial Tumour Expansion, H. Nilsson, D. E. Costea*, M. K. Otterlei, E. Neppelberg, O. K. Vintermyr, I. C. Mackenzie, and A. C. Johannessen, First Congress of the International Academy of Oral Oncology (IAOO), Amsterdam, May 17-20, 2007, oral presentation.
Recapitulating the features of mild, moderate and severe dysplasia using keratinocytes derived from clinical lesions and artificial connective tissue supports, Partridge Max, Costea Daniela Elena*, Gaballah Kamis, Hills Allison, Harrison Paul, First Congress of the International Academy of Oral Oncology (IAOO), Amsterdam, May 17-20, 2007, poster.
Khat Inhibits Proliferation of Normal Oral Keratinocytes in Monolayers and Organotypic Cultures, Lukandu Ochiba, Dimba Elisabeth, Vintermyr Olav, Costea Daniela*, Johannessen Anne, First Congress of the International Academy of Oral Oncology (IAOO), Amsterdam, May 17-20, 2007, poster.
Mitochondrial Damage Is an Early Indicator of Khat-induced Cytotoxicity, O. Lukandu*, D.E. Costea, E. Dimba, O. Vintermyr, and A. Johannessen, IADR/AADR/CADR 85th General Session and Exhibition, March 21-24, 2007, New Orleans, US, poster.
Characterisation of Khat Induced Cell Death in Oral Fibroblasts, OM Lukandu*, D.E. Costea, T. Bredhold, E. Dimba, O. Vintermyr, and A. Johannessen, 3rd Meeting of the Pan European Federation and NOF, 2006, September 13-16, Dublin, Ireland.
Characterisation of Khat Induced Cell Death in Oral Fibroblasts, 3rd Meeting of the Pan European Federation and NOF, 2006, September13-16, Dublin, Ireland.
Normal Keratinocytes and Fibroblasts Control Oral Cancer Cell Expansion, H. Nilsson*, M.K. Otterlei, D.E. Costea, O. Vintermyr, I. Mackenzie, A. Johannessen, and E. Neppelberg, 3rd Meeting of the Pan European Federation and NOF, 2006, September 13-16, Dublin, Ireland.
Spontaneous sorting of fibroblasts and keratinocytes in organotypic oral mucosa, D.E. Costea*, K. Kulasekara, E. Neppelberg, O. Vintermyr, and A. Johannessen, 84th General Session & Exhibition of IADR, 2006, June 28-July 1, Brisbane, Australia.
Differentiation of oral epithelium is regulated by GM-CSF and KGF at early but not terminal stages, D.E. Costea*, K. Kulasekara, E. Neppelberg, O. Vintermyr, and A. Johannessen, 13th International Congress on Oral Pathology and Medicine, 2006, 21 – 25 June 2006 in Brisbane, Australia.
Mechanisms of apoptosis induction by khat alkaloids in leukaemia cells Dimba* EAO, Bredholt T, Costea DE, Francis GW, Johannessen AC, Vintermyr OK, Gjertsen BT, First African and Middle-East IADR Federation Conference, Kuwait, September 27-29, 2005.
Stromal fibroblasts modulate tumuor invasion and expression of basement membarne proteins in in vitro models of normal and neoplastic oral mucosa Kulasekara KMKK*, Lukandu OM, Costea DE, Vintermyr OK, Johannessen AC, 5th Annual CIH Students’ Scientific Conference, Oslo, Norway 29th -30th of April 2005.
Basement membrane proteins during in vitro tumour progression K.K. Kulasekara*, D.E. Costea, G. Øjordsbakken, O.K. Vintermyr, A.C. Johannessen, 10th International Congress on Oral Cancer, , 19-24th April 2005.
Keratinocyte Sensitivity To Fibroblast-Derived Differentiation Signals Is Gradually Lost During In Vitro Tumour Progression, D.E. Costea, G. Øjordsbakken, K.K. Kulasekara*, O.K. Vintermyr, A.C. Johannessen, 10th International Congress on Oral Cancer, Greece, 19-24th April 2005, Best Basic Science Poster Award.
Species-Specific Fibroblasts Trigger Invasiveness of Early Neoplastic Oral Keratinocytes D.E. Costea*, L.L. Loro, K.K. Kulasekara, O.K. Vintermyr, A.C. Johannessen 83rd general session of IADR, Baltimore, MD, US, 6-12th of March 2005.
Artificial human oral mucosa – new tools in dental research D.E. Costea*, O.K. Vintermyr, A.C. Johannessen Landsmøtet for Tannhelsepersonell, Oslo/Lillestrøm, 14-16th of October 2004.
Invasion Of Early Neoplastic Oral Keratinocytes Is Triggered By Species-Specific Diffusible Factors Produced By Underlying Fibroblasts D.E. Costea*, L.L. Loro, K.K. Kulasekara, O.K. Vintermyr, A.C. Johannessen, 12th International Congress on Oral Pathology and Medicine, Madrid, Spain, 6-11th of September 2004, Young Investigator Award of the Spanish Society of Oral Medicine.
Significance of epithelial-mesenchymal interactions for morphogenesis of in vitro reconstituted dysplastic human oral epithelium D.E. Costea*, L.L. Loro, K.K. Kulasekara, O.K. Vintermyr, A.C. Johannessen, NOS-M Symposium on “Oral Precancer and Cancer”, Copenhagen, Danmark, 3-5th of September 2004.
Underlying fibroblasts modulate tumour progression of early neoplastic oral keratinocytes D.E. Costea*, L.L. Loro, K.K. Kulasekara, O.K. Vintermyr, A.C. Johannessen CED/NOF/ID International Association for Dental Research 2004, Istanbul, Turkey, 25-28th of August 2004. Hatton award (first prize) for the NOF division of IADR.
Fibroblasts modulate the pattern of epithelial cell death in vitro reconstructed human oral mucosa through a mechanism independent of keratinocyte growth factor synthesis D.E. Costea*, L.L. Loro, A.E.O. Dimba, O.K. Vintermyr, A.C. Johannessen 4th Annual CIH Students’ Scientific Conference, Bergen, Norway 13-14th of May 2004, Best presentation award (second prize).
Fibroblasts but not keratinocyte growth factor modulate the pattern of cell death in reconstituted human oral epithelium D.E. Costea*, L.L. Loro, A.E.O. Dimba, O.K.Vintermyr, A.C. Johannessen, 9th International Congress on Oral Cancer, Melbourne, Australia, 16th –19th of November 2003. Young investigator award for oral pathology and oral medicine section.
The effects of fibroblasts on human oral epithelial differentiation D.E. Costea, L.L. Loro, A.E.O. Dimba, O.K.Vintermyr, A.C. Johannessen*, 17th Congress of the East and Southern Africa Division, IADR, Arusha, Tanzania, 29th-31st of October 2003.
The concept of lichenoid reaction; can use of organotypic cell cultures contribute to elucidate disease mechanisms? A.C. Johannessen*, oral presentation, European Dental Materials Conference, Bergen, Norway, September 4-5, 2003.
The Effects of Fibroblasts and Keratinocyte Growth Factor on Morphogenesis of Reconstituted Human Oral Epithelium D.E. COSTEA*, E.A.O. DIMBA, L.L. LORO, G. ØIJORDSBAKKEN, O.K. VINTERMYR, and A.C. JOHANNESSEN, oral presentation, The 81st General Session of the International Association for Dental Research Goteborg, Sweden,June 25-28, 2003.
Cytotoxic Effects of Khat (Catha edulis) on Human Oral Cells and Leukemia Cell Lines
E.A.O. DIMBA*, D.-E. COSTEA, L.L. LORO, B.T. GJERTSEN, F.W. GEORGE, O.K. VINTERMYR, and A.C. JOHANNESSEN The 81st General Session of the International Association for Dental Research Goteborg, Sweden,June 25-28, 2003.
Tooth Loss and Initial Prognosis vs. Outcome in a Periodontal Practice in Norway
Ø. FARDAL*, Private Practice, Egersund, Norway, A.C. JOHANNESSEN, Faculty of Dentistry, Bergen, Norway, and G.J. LINDEN, Queen’s University, Belfast, United Kingdom, poster, The 81st General Session of the International Association for Dental Research
Goteborg, Sweden,June 25-28, 2003 .
Mutational Analysis of bcl-2 Gene in Dysplastic and Neoplastic Oral Squamous Epithelia
L.L. LORO*, M.C. MARTHINUSSEN, A. JOHANNESSEN, and O. VINTERMYR, poster, The 81st General Session of the International Association for Dental Research, Goteborg, Sweden,June 25-28, 2003.
Altered Expression of CD40 and CD40 Ligand: Putative Role in the Pathogenesis of Oral Lichen Planus E. NEPPELBERG*, L.L. LORO, A.C. JOHANNESSEN, oral presentation,The 81st General Session of the International Association for Dental Research, Goteborg, Sweden,June 25-28, 2003.
An Immunohistochemical Study of p16 and p21 Expression in Oral Squamous Cell Carcinoma (OSCC) from Two Populations of Different Geographical Origin. A Comparison Between Romania and the Sudan, M. MARTHINUSSEN CUIDA, M.J. IBRAHIM, G. ØIJORDSBAKKEN, E.N. VASSTRAND, and A.C. JOHANNESSEN*, poster, The 81st General Session of the International Association for Dental Research, Goteborg, Sweden,June 25-28, 2003.
Proliferation, differentiation and cell death in organotypic serum free cultures of normal human oral mucosa, Costea D.E.*, Dimba E.O., Loro L.L., Johannessen A.C., Vintermyr O.K
oral presentation, 8th International Congress on Oral Cancer, Rio de Janeiro, Brazil, 29th of Nov- 2nd of Dec 2002.
An Immunohistochemical study of p53 and p21 expression in oral squamous cell carcinoma (OSCC) by using two different methods of detection. Marthinussen*, Mihaela Cuida; Cionca, L; Ganuta, N; Øijordsbakken, Gunnvor og Johannessen, Anne Christine. I: 2nd World Congress of the International Federation of Head and Neck Oncologic Societies, 8th International Congress on Oral Cancer. India: Rajkamal Electric Press; 2nd World Congress of the International Federation of Head and Neck Oncologic Societies, 8th International Congress on Oral Cancer. Rio de Janeiro, Brasil, 27. nov – 2. des 2002.
Cytotoxic effects of Catha edulis on human oral cells in vitro Dimba* EO, Costea DE, Loro L.L., Johannessen A.C., Vintermyr O.K., poster, European Festival of Oral Science, Inaugural meeting of Pan European Federation International Association of Dental Research, Cardiff, Wales, 25th-28th September 2002 Hatton award (second prize) for the NOF division of IADR.
Serum free organotypic cultures of normal human oral mucosa Costea D.E.*, Dimba E.O., Loro L.L., Johannessen A.C., Vintermyr O.K., poster, European Festival of Oral Science, Inaugural meeting of Pan European Federation International Association of Dental Research, Cardiff, Wales, 25th-28th September 2002.
Cytotoxic effects of Catha edulis on leukemia cell lines. Dimba, Elizabeth Anne; Dickinson, Anne M.; Loro, Lado Loko; Johannessen, Anne Christine og Vintermyr, Olav Karsten. IADR Regional meeting E and S Africa. Johannesburg, Sør-Afrika, 14. – 18. aug 2002.
Angiolymphoid hyperplasia with eosinophilia. Johannessen, Anne Christine. Foredrag, 23. møte i Skandinavisk forening for oral patologi og oral medisin. Umeå, 16. – 18. aug 2002.
Oral Malignant Melanoma:A case report. Loro, Lado Lako og Johannessen, Anne Christine. Foredrag, 32nd SFOPOM meeting. Umeå, Sverige, 16. – 18. aug 2002.
Gene expression profile in oral squamous cell carcinomas and matching normal oral mucosal tissues from black Africans and white Caucasians: The case of the Sudan vs. Norway. Ibrahim, Salah O.; Aarsæther, Niels; Holsve, Marianne; Kross, K. W.; Heimdal, J. H.; Aarstad, Hans Jørgen; Liavaag, Per Gunnar; Elgindi, O. A-Aziz; Johannessen, Anne Christine; Lillehaug, Johan R. og Vasstrand, Endre N. International Journal of Cancer 2002; (Suppl 13):405. 18th UICC International Cancer Congress. Oslo, 30. jun – 5. jul 2002.
Tumour necrosis factor receptor superfamily members 1a, 1b, 5, 6 and their ligands in oral squamous cell carcinoma. Loro, Lado Lako; Vintermyr, Olav Karsten; Jonsson, Roland og Johannessen, Anne Christine. Scandinavian Journal of Immunology 2002; 55(5):528. Scandinavian Society for Immunology 33rd Annual Meeting and Scandinavian Society 18th Summer School. Bergen, 24. – 28. apr 2002.
Establishment of organotypic cultures of normal human oral mucosa Costea D.E.*, Dimba E.O., Loro L.L., Johannessen A.C., Vintermyr O.K, oral presentation, 3rd Bergen Conference on Cancer Research, Osøyro, Norway, 26th-27th of April, 2002.
Cytotoxic effects of Catha edulis on leukemia cell lines and primary human oral cells. Dimba, Elizabeth Anne; Costea, Daniela-Elena; Loro, Lado Lako; Johannessen, Anne Christine og Vintermyr, Olav Karsten. 3rd Annual Student’s Scientific Conference 11-12 April 2002, Program & Abtracts. 2002. s. 3-3 3rd Annual Student’s Scientific Conference. Best presentation award.
Current methods in oral cancer research Costea* DE, Ibrahim* M, Dimba* EO
oral presentation, 2nd Annual CIH Students’ Scientific Conference, Bergen, Norway, 10th-11th of May 2001.